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(0:00) Autoimmune risk: genetics vs environment (1:13) Exclusive offer for Health Decoded listeners (1:40) Understanding the Autoimmune Explosion (6:49) Early warning signs and common autoimmune conditions (12:28) Testing and root cause detection in autoimmunity (13:06) Sponsor: Authentic Nutrition (14:03) The importance of functional testing in managing autoimmunity (19:15) Comprehensive anti-autoimmune strategies (26:15) Engaging with Health Decoded: Call to action and resources (27:09) Outro: Contact details and final thoughts00:00:00
Only about twenty five to thirty percent of autoimmune risk is genetic.
00:00:04
The rest is very much environmental and lifestyle exposure.
00:00:08
So your genes may load the gun, but your environment is what pulls the trigger.
00:00:12
Welcome to Health Decode, your number one source for real health information with your
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host, doctor Alessi and Matt Tack.
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Hey, Health Decoded listeners.
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Welcome back to another episode of Health Decoded.
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I am your host, Doctor.
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Alfred Lessie, and I'm thanking you for joining us today.
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Very excited to talk about what we are discussing today, which is really the
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autoimmune explosion, we call it in this country, and why your body is attacking itself,
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why this has been so rampant as of late, and ultimately, how to stop the fire that's burning
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inside.
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So again, thank you so much for joining us.
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We always appreciate our listeners and we want to just deliver as much valuable knowledge and
00:02:29
information as we can to help as many people as possible.
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This podcast is free.
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We do not take a dollar or anything like that.
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We just ask that you share if you've been finding value in this show.
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That being said, let's get started.
00:02:42
So why is it that your body is suddenly turning against itself from things like Hashimoto's to
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lupus, rheumatoid arthritis?
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Autoimmune disease is exploding.
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In this episode, we are going to break down what's really happening under the surface, why
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standard treatments often miss the mark, and how to take back control of your immune system
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and your life.
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So before we get into any of that, we need to discuss what is autoimmunity and why is it on
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the rise?
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So, autoimmunity is not your body betraying you, it's your immune system getting confused.
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Instead of defending you, it misfires and starts attacking your own tissues, mistaking
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them for foreign invaders.
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So, basically within the science, it shows that your immune system is supposed to be a smart
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defense system.
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It has really two critical jobs.
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Number one is to defend against invaders like bacteria, viruses, and toxins.
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And number two, to tolerate your own cells and tissues.
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This second job, immune tolerance, is where things go wrong in an autoimmune condition.
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So, your body loses this tolerance, it begins to see normal tissues like your thyroid, your
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joints, skin or even your brain as threats.
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This triggers a chronic inflammatory cascade leading to tissue damage and a cascade of
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symptoms that can affect virtually every system in the body.
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There are over 80 distinct autoimmune diseases that have been identified, including some of
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the most common that we see, Hashimoto's thyroiditis, multiple sclerosis, lupus, celiac
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disease, psoriasis, rheumatoid arthritis, type one diabetes, and ulcerative colitis and
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Crohn's disease.
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Collectively, these conditions affect more than fifty million Americans and the numbers are
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rapidly climbing.
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So why this explosion?
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Why does this once rare condition now become such a norm and what has changed?
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Here's really what's been driving that rise.
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Things like leaky gut or intestinal permeability, something we discussed in a
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podcast previously.
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Your gut is supposed to act like a selective barrier, but when it gets leaky, undigested
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food particles and bacteria and toxins can slip through into the bloodstream.
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This then triggers an immune response.
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And for genetically predisposed individuals, that response can then spiral into
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autoimmunity.
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Things like environmental toxins.
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We're exposed to more toxins than ever before.
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Mold, heavy metals, things like mercury, pesticides like glyphosate, and industrial
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chemicals.
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These compounds can disrupt immune regulation and trigger immune misfiring.
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Chronic infections, viruses like Epstein Barr virus or stealth pathogens like Lyme disease.
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These can hijack immune function and create long term immune confusion.
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In some cases, molecular mimicry occurs, where the body mistakes its own tissues for a virus
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and begins attacking them.
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This is actually a built in mechanism for those viruses to survive.
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Things like poor diet and chronic stress, ultra processed foods in the modern Western lifestyle
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is an autoimmune trigger factory.
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Refined sugars and seed oils, artificial additives, stress hormones all impair your gut
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health, increasing inflammation and overloading your immune capacity.
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Genetics also play a role, but they're only part of the story.
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Only about twenty five to thirty percent of autoimmune risk is genetic.
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The rest is very much environmental and lifestyle exposure.
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So, your genes may load the gun, but your environment is what pulls the trigger.
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Now, I think there is some silver lining to that basically saying that we can take control
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of our environment and our lifestyle to fight against these kinds of things.
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There was a study in The Lancet 2021 that basically said the incidence of autoimmune
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disease has increased significantly over the past thirty years, largely due to environmental
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and lifestyle changes.
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So, the key takeaway here is that autoimmunity, it's not random.
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It's not just bad luck, bad genes.
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Oh, I got this from my parents.
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It's a breakdown in communication between your immune system, your gut, and your environment.
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If we can remove the confusion, we can restore balance, and that's where the real healing
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begins.
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So, now let's talk about what are some early warning signs, what we call the silent storm
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before the diagnosis.
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There's a very amazing concept by a doctor named Doctor.
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Steven Cabral who I actually studied under that he patented called the rain barrel effect.
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Essentially, people used to use rain barrels to collect the rainwater and then use that water
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to then water their crops, their plants, whatever they used it for.
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Now, the concept here is that everything that affects your body is like filling up that rain
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barrel.
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Exposure to toxins, the rain barrel fills up.
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Ultra processed food consumption, the rain barrel fills up.
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Chronic stress, all these things start to build that up.
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It's not until that rain barrel overflows or tips over that we call disease state, right?
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So, we're constantly building this progression until one day disease has set in.
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But that process started a long time ago.
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So the concept is that these autoimmune diseases, they don't just show up.
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They brew quietly for years.
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Most people will experience vague, kind of frustrating symptoms long before they ever get
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a diagnosis.
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That's why recognizing early warning signs is critical for prevention and early intervention.
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Autoimmunity is really a slow burn process.
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You don't just wake up one day with full blown lupus, Hashimoto's or RA.
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Instead, your immune system begins to misfire little by little, sending you signals that
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something's off.
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But those signals often get dismissed or misdiagnosed as stress, aging, anxiety, or air
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quotes, just normal.
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But they're really these early warning signs.
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So, of the common early warning signs, and these are really red flags that may seem
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random, but together they form a pattern of immune dysfunction.
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Things like chronic fatigue that doesn't improve with rest.
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Brain fog or difficulty concentrating, joint pain or stiffness, especially in the morning,
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digestive issues, bloating, IBS, constipation or sensitivity to gluten, skin flare ups like
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eczema, hives, unexplained rashes, mood swings like anxiety or depression, cold hands and
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feet, hair thinning, brittle nails, dry skin, irregular menstrual cycles or an increased PMS.
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And then food and supplement sensitivity, suddenly reacting to things that you used to be
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able to tolerate is a huge red flag.
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These are not just annoying symptoms, they're your body waving a flag, hey, something deeper
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is going on.
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So, some conditions to know and then their sneaky presentations and how do we link these
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together, right?
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Now again, this is just a symptom check, not an actual diagnostic tool, but something to be
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aware of to then, hey, do I need to take further intervention, run some type of
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diagnostic lab work, stool test, whatever it may be.
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So, with Hashimoto's thyroiditis, this is the most common autoimmune condition in women.
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Early signs are going to look like fatigue and anxiety, weight gain that doesn't improve with
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exercise and diet, hair loss, and constipation.
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Often mistaken for hormone imbalance or just being tired.
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Get that thrown around all the time.
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Celiac disease, this is on the rise as well.
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Gluten basically triggering an immune attack on the small intestine.
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It may present at first with bloating, brain fog, nutrient deficiencies or even no gut
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symptoms at all until it's full blown, you start to get these more elevated symptoms.
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And it is often commonly missed or misdiagnosed as IBS.
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Psoriasis.
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This is an autoimmune driven overproduction of skin cells.
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Basically, the early signs are the dry patches, often on the elbows, knees or scalp or pitting
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of the nails.
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And this can often flare with stress, illness or certain foods.
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And then rheumatoid arthritis.
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This is going to affect the joints, especially the hands, wrists and feet, the smaller joints.
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Early signs are morning stiffness, swollen joints, fatigue, often brushed off as like, Oh,
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I'm just getting older, or This is overuse.
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So, it's very critical that we start to take intervention or take thought of what's going
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on.
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There was a study done in the journal Autoimmunity Review of 2019.
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Autoimmune disease typically begins with nonspecific symptoms that often go unrecognized
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for years before a diagnosis.
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This means that by the time someone gets diagnosed, the immune system has likely been
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dysregulated for five to ten years.
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So, don't wait until your labs are bad enough to get help.
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If you are experiencing a constellation of vague but chronic symptoms, it's time to dig
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deeper.
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Your body whispers before it screams, so start listening now, and you may be able to help stop
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autoimmunity before it takes root.
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Now, I want to discuss the type of testing and root cause detection that we call the don't
00:12:34
guess test approach.
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Now back to the episode.
00:14:03
Alright.
00:14:04
Welcome back.
00:14:05
Now let's get into it, testing and root cause detection.
00:14:08
The idea here is we don't guess, we test.
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Because autoimmune disease is not a diagnosis you just stumble into.
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It's a condition that you can detect much earlier with the right labs.
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But most conventional tests are limited to diagnosing the disease once it's already
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advanced.
00:14:26
If you truly want to heal, you need to go upstream and you need to look at the root
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causes, especially in the gut, immune system, and your body's total toxic burden.
00:14:36
So, let's get into the labs that really matter.
00:14:38
Let's break it into two categories, diagnosis and root cause detection.
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So, the conventional medicine approach is going to be these autoimmune panels, which are,
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they're useful, they're good for diagnosing, but it's not going to give you the whole
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picture.
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One is called an ANA, an antinuclear antibody panel.
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This screens for general autoimmunity, often the first step for lupus or connective tissue
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disorders.
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A positive result basically says something's off, but it's nonspecific.
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TPO and thyroglobulin antibodies.
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This is how we detect Hashimoto's thyroiditis, which is the most common autoimmune condition.
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These should be tested alongside TSH and free T3 and T4, not instead of them.
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And so, oftentimes we'll get one or the other when we need the whole picture.
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The next one is anti CCP and rheumatoid factor.
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These are specific markers for rheumatoid arthritis.
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Elevated levels are basically saying that your immune system is attacking your joints.
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And then a celiac panel, which is a TTG IgA and a total IgA.
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This screens for gluten triggered autoimmune reactions.
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However, be aware, some people will test negative but still have a non celiac gluten
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sensitivity driving inflammation.
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That's where functional medicine comes in.
00:16:07
We use some tests that are not even known about in conventional medicine.
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People don't even understand how to read these tests, but we're able to look more at root
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cause factors.
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So, this is where the real answers start to emerge because we can use things like a
00:16:23
comprehensive stool analysis to test for parasites, candida, bacterial overgrowth, and
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leaky gut markers like zonulin, as well as inflammation and more.
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Because gut dysbiosis is one of the biggest root drivers of autoimmune disease.
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Go back to episode 16 and listen to that, and it will explain how this process works.
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Food sensitivity testing.
00:16:48
Looking at the IgG and the IgA responses.
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Basically, of your immune system and those IgG and IgA cell factors as like the policeman.
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The IgG is more like your general police squad, the cops.
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Right?
00:17:06
That they show up and they kind of handle the basic stuff.
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And the IgA is like the SWAT team.
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When the IgA is elevated, there is an issue.
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Something big is going down.
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And this is going to identify delayed immune responses to common foods.
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So, it's important to note that food sensitivities are often a symptom of leaky gut,
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but often cannot be the primary cause as well.
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So, that's when we need to explore more things.
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Mycotoxin and mold exposure testing.
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Mold can trigger and worsen autoimmunity, especially in genetically susceptible
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individuals.
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It's very common in those with the unexplained fatigue, sinus, brain fog type of issues.
00:17:45
And then as well as heavy metal testing.
00:17:47
So, toxic metals are going to impair the immune regulation and promote autoimmunity.
00:17:53
This is especially relevant if you've had amalgam fillings or a past chemical exposure or
00:17:59
a history of chronic infections.
00:18:00
So a study out of the journal Frontiers in Immunology twenty twenty showed that increased
00:18:05
intestinal permeability plays a critical role in the development of autoimmune diseases.
00:18:11
This is something that was historically more of a fringe theory.
00:18:16
Just ten years ago, Western medicine didn't even recognize leaky gut.
00:18:20
Now, this is shown to have been proven as this is a real condition.
00:18:23
This is a real thing leading to autoimmune disease.
00:18:27
And so, what is the mindset shift we need to make here?
00:18:31
If your labs are normal and you still feel like garbage, you're not crazy, right?
00:18:36
How many times have I seen patients, I could count it, that they come in and they said, The
00:18:40
doctors told me I'm just, I'm crazy.
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I'm fine.
00:18:44
No, you're probably just not looking in the right place.
00:18:47
Standard labs look for disease, functional testing looks for dysfunction.
00:18:52
And that's where you'll find the earliest clues.
00:18:54
So, what's the takeaway here is that autoimmune disease rarely begins in the blood.
00:18:59
It begins in the gut, the environment, and the immune system's interpretation of both.
00:19:05
So, you need to run the right tests and you'll see the real root causes unfold.
00:19:10
That is when healing becomes possible.
00:19:12
So now, how do we take what we just learned?
00:19:15
We get a diagnosis or we get an early detection and start to calm the fire and rebuild your
00:19:21
immune tolerance before the autoimmune sets in.
00:19:25
So, I always like to tell my patients, this is not a life sentence, an autoimmune condition.
00:19:30
It's a signal that your body is inflamed, overwhelmed, and confused.
00:19:34
The key now is to remove the triggers, heal the gut, and rebalance the immune system so your
00:19:40
body stops attacking itself.
00:19:43
You don't have to suppress your immune system with medication for the rest of your life.
00:19:47
You can retrain it to do its job properly again.
00:19:50
So, we implement what we consider the five part anti autoimmune strategy.
00:19:57
We are all about protocols, because protocols are a system that has been proven to work.
00:20:02
This is similar to what we discussed in a previous episode, episode 16, about our five
00:20:08
R's for balancing gut health.
00:20:10
This is similar to that.
00:20:11
So, step one is you need to remove the triggers.
00:20:15
You cannot put out a fire while pouring gasoline on it.
00:20:18
So, you need to eliminate inflammatory foods for thirty to ninety days, if not forever,
00:20:23
right?
00:20:24
Gluten, dairy, refined sugar, seed oils, soy, processed junk foods.
00:20:29
These realistically just have no place being ingested.
00:20:32
You need to get rid of chemical exposures to things like BPA, plastic, glyphosate laden
00:20:37
foods, toxic beauty products and artificial fragrances.
00:20:41
There's an app you can get called Think Dirty, where you can scan the barcode of any product
00:20:47
that you put on your body, any beauty products, hair, shampoos and it will tell you if that
00:20:53
thing is loaded with chemicals.
00:20:55
You need to treat gut infections like Candida, parasites, or SIBO, which can be found through
00:21:00
the stool testing.
00:21:02
And then cleaning up the environment.
00:21:04
Getting a water filter in your home, testing your home for mold, reducing the EMF load if
00:21:09
you're sensitive to that, turning off the Wi Fi at night.
00:21:13
All of these things are how we remove those triggers.
00:21:16
Step two, now we need to repair the gut barrier.
00:21:19
Healing the gut is going to calm the immune confusion.
00:21:22
So we use gut healing nutrients like L glutamine, zinc, collagen, slippery elm, and
00:21:29
aloe vera.
00:21:30
I'm not going to get deep into this because we just discussed this in episode 16, so you
00:21:34
should go back and listen to that.
00:21:36
Step three, we need to rebalance the immune system.
00:21:39
Now, you calm the overreaction, you start to rebuild tolerance.
00:21:43
Vitamin D is a powerful immune modulator.
00:21:47
The optimal blood range is somewhere between fifty to seventy nanograms per milliliter.
00:21:52
And most people are deficient.
00:21:54
It's very common for people to be deficient.
00:21:56
Oddly enough in Florida, we are very deficient in vitamin D because we overuse sunscreens and
00:22:02
protection, not allowing ourselves to get sunlight.
00:22:06
So, omega-3s from wild caught fish or high quality fish oil are going to cool
00:22:10
inflammation.
00:22:11
Probiotics and prebiotics will restore the healthy microbial balance.
00:22:15
The microbiome is where our immune system lives.
00:22:18
And then fasting, short fasting hours from twelve to sixteen hours can reduce the
00:22:22
inflammation, promote autophagy, and improve immune signaling.
00:22:27
Go listen to episode 17 where we got heavy into the fasting and the protocol associated.
00:22:33
Step number four, lower your stress burden.
00:22:36
Stress is basically the gas pedal on autoimmunity.
00:22:40
It's gonna activate the HPA axis, which is gonna increase cortisol dysregulation and thus
00:22:45
immune dysfunction.
00:22:47
Prioritize seven to nine hours of sleep.
00:22:49
Track it, protect it.
00:22:51
Make sure your sleep and wake times are the same.
00:22:54
That's how you restore that circadian rhythm.
00:22:58
Practice some type of daily stress reduction, whether it's prayer, meditation, breath work,
00:23:03
or nature therapy.
00:23:04
Get outside and move.
00:23:06
Gentle movement is greater than chronic cardio, right?
00:23:11
So, going and running and pounding, pounding until your body is just beaten is not going to
00:23:15
help you.
00:23:15
A gentle walk plus some strength training.
00:23:18
These things are going to benefit the immune system.
00:23:20
And then you can consider some adaptogens, things like ashwagandha, rhodiola, or holy
00:23:25
basil as tolerated.
00:23:26
These can improve your body's response to stress and that cascade of the negativity that
00:23:33
comes with chronic stress.
00:23:35
And then step five, this is the fun part.
00:23:37
We get to reintroduce foods cautiously.
00:23:40
Once inflammation is down, gut function improves, you can start reintroducing foods
00:23:45
that may be used to create sensitivity one at a time.
00:23:49
So, three to five days we'll start to build in some of these foods and see how the body
00:23:54
responds.
00:23:54
And oftentimes the person can heal from a food sensitivity.
00:23:59
You need to track how you feel, your energy, digestion, mood, skin.
00:24:04
Are there flare ups?
00:24:04
Are there relapses?
00:24:06
If a food causes a symptom, you pull it out again and then you can try again later.
00:24:11
It's not about restriction for life.
00:24:14
This is about listening to your body and finding your personal blueprint.
00:24:18
We're all different biologically and our biochemistry changes as well.
00:24:22
And so we can heal from certain food sensitivities, but some people are just
00:24:27
predisposed to certain things based on where they were born, the things they did as a child,
00:24:32
the food they were exposed to early on, that created certain patterns.
00:24:37
So, there's an awesome study out of the Journal of Immunological Research in 2021 that said
00:24:43
that restoring the gut barrier integrity and microbial balance can reestablish immune
00:24:48
tolerance and reduce autoimmune symptoms.
00:24:51
Everything begins in your gut.
00:24:54
So, final takeaway here, autoimmunity is not random.
00:24:58
It's not, Oh, I just got this thing.
00:25:00
I guess I'm stuck with this.
00:25:02
It's a survival mechanism that's gone haywire due to our toxic inflammatory world.
00:25:07
Your job is to give your immune system the clarity and support it needs to stop firing at
00:25:13
shadows.
00:25:15
And that starts with the gut.
00:25:16
That starts with the environment.
00:25:18
And that starts with your daily habits, not a lifetime of suppressive medication.
00:25:24
So, if autoimmune disease is the fire, it always starts with a spark.
00:25:29
Your job isn't just to treat the flames, it's to find and remove what's feeding them.
00:25:34
If you found this episode helpful, please share this with someone that you know that maybe is
00:25:39
dealing with some of these symptoms, or yourself, and remember healing is possible when
00:25:44
you stop fighting your body and you start listening to it.
00:25:48
If you would like to learn more about how we help people to diagnose, reverse, and heal
00:25:53
autoimmune conditions within our functional medicine programs, go to
00:25:57
alessifunctionalhealth.com, schedule a consultation with myself or one of my
00:26:02
providers, and let's create a personalized plan for lifelong health.
00:26:07
Listeners of this podcast are always going to get exclusive discounts and price reductions on
00:26:12
all of our protocols and lab tests.
00:26:15
As always, if you found value in today's show, please hit that like button, subscribe to the
00:26:20
show, and share this with someone who needs to hear it.
00:26:24
That is the only way we grow this message and can change more lives.
00:26:28
If you want to get in touch with us, or be featured on an episode, email us your questions
00:26:32
to askalessiefxhealth dot com.
00:26:35
We love to highlight our patients and our success stories.
00:26:39
Then always visit AlessiFxHealth.com, sign up for our newsletter.
00:26:43
That's where you're going to be in the know about everything going on, and you can check
00:26:47
out our resource page to learn more about our approach to nutrition and cutting edge
00:26:52
therapies.
00:26:53
As always, thank you for tuning into Health Decoded, where we're here to break down the
00:26:57
science, bust the myths, and help you take control of your health naturally.
00:27:02
Until next time, stay curious, stay empowered, and remember, your health is in your hands.
00:27:09
Thank you for tuning in to Health Decoded, where we break down the truth about all things
00:27:15
health and empower you to take charge of your well-being.
00:27:18
If you found value in today's episode, please subscribe, leave a review, and share it with
00:27:23
someone who needs to hear this.
00:27:25
For more resources and personalized support, visit us at AlessiFunctionalHealth.com and sign
00:27:31
up for our newsletter.
00:27:33
To hear your questions answered live on the show, send them to ask@AlessiFXHealth.com.
00:27:39
That's ask@alessifxhealth.com.
00:27:44
Until next time, stay curious, stay empowered, and remember, your health is in your hands.