Webinar Link https://gut.alessifunctionalhealth.com/main-page
(0:00) Introduction, welcome, and overview of chronic symptoms and gut health (1:28) Announcement of free webinar on gut health (1:50) Introduction to neuroinflammation and its impact (2:49) Episode roadmap: understanding, symptoms, testing, and solutions (3:29) Brain’s immune system, microglia, and chronic neuroinflammation (4:57) Blood brain barrier, systemic inflammation, and brain-body connection (6:34) Symptoms of neuroinflammation: cognitive, mood, and physical signs (9:34) The need for comprehensive and advanced testing (13:27) Functional medicine’s approach to neuroinflammation (14:19) Actionable steps to address neuroinflammation (14:50) Dietary changes to reduce inflammation (16:21) Importance of quality sleep for brain health (17:44) Managing stress and targeted supplementation (21:43) Exercise and detox strategies for inflammation (25:15) Summary, encouragement, and key takeaways (27:08) Call to action for sharing the podcast (27:24) Closing remarks and final sign-off00:00:00
If you have multiple symptoms across multiple systems such as cognitive, mood, physical, and
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nothing in conventional medicine has explained why, it's not one symptom.
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It's a constellation and it tends to be chronic.
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Welcome to Health Decoded, your number one source for real health information with your
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host, Doctor.
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Alessi and Matt Tack.
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Health decoded listeners, if you're dealing with bloating that just won't go away no matter
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what you eat, no matter what you try, I need you to hear this.
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The bloating isn't the problem.
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It's a signal.
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Every external symptom you're experiencing, the discomfort, the fatigue, the frustration, has a
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root cause.
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And in my years of clinical practice, it almost always leads back to the gut.
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Nothing else in your body can fully heal until that foundation is restored.
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I built this framework from my own health journey.
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I was that patient, frustrated, dismissed, searching for answers.
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I took everything I learned, refined it through years of clinical testing, and have since
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helped hundreds of patients achieve complete relief from their symptoms.
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That became the Total Gut Reset, a step by step protocol with one goal, reset your gut in six
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months or less.
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If you're ready to learn exactly what's causing your symptoms and eliminate them for good, I'm
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hosting a free webinar where I walk you through the entire framework.
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The link is in the show notes.
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Go ahead and register, and I'll see you there.
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Welcome back to another episode of Health Decoded.
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I'm your host, doctor Alessi.
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If you've ever felt like your brain was wrapped in wet concrete, foggy, slow, exhausted,
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inflamed, this episode is for you.
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I wanna welcome you back to the Health Decoded podcast.
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I'm your host, doctor Lesse, and today, we're diving deep into one of the most
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underdiagnosed, misunderstood and frankly underappreciated drivers of chronic
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inflammation that I see in my practice every single week.
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We're talking about neuroinflammation.
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This is inflammation of the brain and nervous system.
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Now, when most people hear the word inflammation, they think of maybe a swollen
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knee or a red and infected wound.
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Yes, that is inflammation.
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But what happens when that same inflammatory process is happening quietly, silently inside
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your brain?
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That's what we're talking about today.
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Here's a little roadmap of what we're gonna go through today.
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First, what is neuroinflammation?
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Like what it actually is, the biology, I'm gonna explain that.
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Second, the signs and symptoms, and I promise some of these are actually gonna surprise you.
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And third, how we test for it.
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Because if you can measure it, you can manage it.
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And then the last segment we'll go through the part that everyone wants is what can you
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actually do about it?
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Actionable root cause strategies that work.
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So let's just get right into it.
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So basically what exactly is neuroinflammation?
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At its most fundamental level, neuroinflammation is an immune response.
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Specifically an immune response that occurs within the brain and central nervous system.
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Now here's something most people don't know.
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Your brain has its own immune system.
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It has specialized immune cells called microglia.
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These are the brain's resident defenders.
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They constantly scan for threats, pathogens, damaged cells, toxic compounds, anything that
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shouldn't be there.
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When microglia detect a threat, they activate.
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They release inflammatory signals called cytokines.
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This is actually a brilliant and necessary survival mechanism.
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Acute inflammation, the short term kind, is your body doing its job perfectly.
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Now, the problem is when that immune response doesn't turn off.
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Think of it like this.
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Imagine you set off a smoke alarm in your kitchen because you burned some toast.
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The alarm is doing exactly what it should.
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But now imagine that alarm just keeps going and going.
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Hours later, days later, you've cleaned up the toast, opened the windows, the smoke is gone,
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but that alarm is still blaring.
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That's chronic neuroinflammation.
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The alarm is stuck in the on position.
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And when your brain is in a sustained state of immune activation, it can't do other jobs well.
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Memory consolidation, mood regulation, executive function, energy metabolism and
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hormone signaling, all of this gets compromised, put on the back burner.
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And so there's another layer to this that I really want you to understand.
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And that's what we've talked about in a previous episode a couple weeks back is the
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blood brain barrier.
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So your brain is protected by a highly selective barrier.
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This is a tight cellular lining that controls what gets in and stays out.
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Nutrients come in, waste products leave, pathogens and toxins are supposed to be
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prevented from entering.
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Here's the problem, when systemic inflammation is chronically elevated, meaning inflammation
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in the rest of the body, that barrier can actually become compromised.
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It becomes what some researchers are calling leaky, similar to the concept of leaky gut.
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When that barrier breaks down, inflammatory compounds that have no business being near your
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neurons start crossing over.
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Example, gut inflammation can even drive brain inflammation.
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Mold toxins, infections, heavy metals, chronic stress hormones all of these compromise the
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blood brain barrier and light up that central nervous system immune response.
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This is exactly why we don't look at the brain just in isolation.
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The brain is downstream of everything else.
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Gut health, immune health, toxic burden, hormones, sleep, stress, you name it.
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When you treat neuroinflammation effectively, you actually have to treat the whole system
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because that's what created the inflammatory environment in the first place.
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So neuro inflammation is not solely a brain problem, it's a body problem that shows up in
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the brain.
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And so here's the frustrating reality about neuro inflammation, It doesn't show up the way
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most inflammatory conditions do.
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You can't see it.
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You can't feel a lump or swelling.
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You won't find it on a standard CBC panel.
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So instead it shows up how you think, how you feel, how you move through the world.
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And because conventional medicine tends to compartmentalize these symptoms, sending you to
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a neurologist for one thing, a psychiatrist for another, an endocrinologist for the other, the
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underlying inflammatory driver never gets addressed.
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What I want to do is walk you through the symptom clusters that I see most frequently
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with my patients when it comes to neuroinflammation.
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The first cluster is cognitive.
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This is brain fog, is the biggest one we see.
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That thick, heavy, can't think straight feeling that doesn't go away even after getting a good
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night's sleep.
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Memory issues, particularly like short term memory, difficulty forming new memories, the
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ability to retrieve words.
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What was I going to say?
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Those kind of things.
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Many of patients describe it as feeling like they're thinking through sludge, difficulty
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concentrating, slow processing speed, a mental fatigue that hits hard in the afternoon.
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All of these fit the neuroinflammatory picture.
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Now the second one is more mood and emotional symptoms.
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This is where the science has gotten really interesting in the last decade.
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We know that depression and anxiety are not purely psychological.
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Inflammation is one of the primary drivers of both.
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When your microglia are activated and your brain is bathed in pro inflammatory cytokines,
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Neurotransmitter production will get disrupted.
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Serotonin, dopamine, GABA, all of these are downstream of your inflammatory state.
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Irritability, low mood, emotional reactivity, feeling flat or unmotivated, heightened
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anxiety.
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These aren't character flaws or just how you're wired.
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In many cases, they're symptoms of an inflamed nervous system.
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The third cluster, this is more physical, see this a lot.
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Headaches, particularly like pressure headaches or headaches that seem to come from nowhere.
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Sensitivity to light or sound.
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Fatigue that is disproportionate to your activity level.
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You're not just tired but like bone deep exhausted.
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Sleep disturbances are huge here as well.
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Many patients with neuroinflammation have trouble either falling asleep or staying asleep
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because their nervous system is stuck in a low grade threat response.
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And then the sleep deprivation makes the inflammation worse.
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It's a very vicious cycle.
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Things like tinnitus, dizziness, autonomic dysregulation, racing heart, temperature
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dysregulation.
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These can all be part of this picture as well.
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Here's the pattern I want you to hold onto.
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If you have multiple symptoms across multiple systems such as cognitive, mood, physical, and
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nothing in conventional medicine has explained why, neuroinflammation needs to be on the
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radar.
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It's not one symptom, it's a constellation and it tends to be chronic, meaning weeks, months,
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sometimes years with varying intensity.
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If any of that sounds familiar, don't panic.
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It's actionable and we're going to get there.
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We're going to go through all of that today.
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Before I go through what we use to assess neuroinflammation, I wanna acknowledge
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something that I hear from patients constantly.
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And it's this, and I could probably count hundreds of times I've heard this.
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My doctor ran my labs and everything came back quote unquote normal.
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That's because standard panels are not designed to evaluate neuroinflammation.
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A basic metabolic panel or a standard CBC, these are not sensitive enough to pick up the
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low grade chronic inflammation that I'm talking about.
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That doesn't mean nothing's wrong, it means you need a more refined and detailed assessment.
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The first category of testing is what we call systemic inflammatory markers.
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These are blood tests that while it's not brain specific, it's gonna give us important signal
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about the overall inflammatory burden that your body is carrying.
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High sensitivity CRP or HSCRP.
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This is one of the most useful and underutilized markers in functional medicine.
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It's highly sensitive to low grade chronic inflammation.
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We want to see this below a one.
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Many patients with neuroinflammation, they come in at like a three, a five or sometimes higher.
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Now the next one, homocysteine.
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This is another critical marker.
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It's associated with both neuroinflammation and cardiovascular risk.
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Elevated homocysteine directly injures the blood brain barrier.
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Ideally, I want to see this below an eight.
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Now ferritin, ESR, fibrinogen, these are markers that can all provide additional
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information about the inflammatory state.
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And so, we look at the whole picture, not just a single number.
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Now, when we want to go deeper, say there's more going on, we can look directly at
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cytokines.
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So, we can test the inflammatory signaling molecules that I had mentioned earlier.
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Tests like TNF alpha, interleukin six, interleukin one beta, all can help us
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characterize the nature and severity of the inflammatory response.
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These aren't always necessary for every patient but for complex cases, particularly ones where
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patients have tried multiple interventions and nothing's gotten better, cytokine panels can be
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incredibly helpful.
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Because the gut brain connection is so fundamental to a neuroinflammation, gut testing
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is often a large part of our workup as well.
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A comprehensive stool analysis like our GutZumer can reveal dysbiosis, intestinal
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permeability or leaky gut, and any infections, All of which will drive systemic and
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neuroinflammation.
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An organic acids test is a great test gives us a window into mitochondrial function,
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neurotransmitter metabolism and any yeast or bacterial overgrowth which are all relevant to
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this neuroinflammatory picture as well.
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Then, of course, depending on the patient's history, we might also screen for mycotoxins,
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mold, heavy metals, Lyme, co infections, reactive Epstein Barr virus or other chronic
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infections.
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These are some of the most common and often most missed drivers of neuroinflammation that I
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see.
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If you've ever had significant mold exposure or a tick bite, a major illness that you never
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quite recovered from, those are red flags that warrant a much deeper investigation than just a
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CBC.
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And so what makes functional medicine different isn't just the tests themselves, it's what we
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do with those results.
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Because I'm not just chasing a diagnosis.
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What good is a diagnosis without a plan?
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We're mapping a system.
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We want to understand where is the inflammatory signal coming from?
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What are the upstream drivers?
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What does this specific patient's body need to down regulate that response and restore
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balance?
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That's the lens that we apply to every test that we run at Ascend Functional Health.
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Now, let's get into the next piece in this segment where everyone always wants to hear
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this part, what can I do?
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What are the action items I can take home?
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And so I want to start by saying something really important.
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Healing neuroinflammation is not about finding the one magic supplement or the silver bullet
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as we call it, the one perfect diet.
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It's about systematically removing what's driving inflammation in the first place and
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rebuilding the environment your brain needs to heal.
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Everything I'm about to share is evidence based, root cause focused, and so I broke it up
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into pillars.
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These are just the main pillars that we focus on.
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Number one, diet.
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We have to remove the fuel from the fire.
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The single most powerful dietary shift for neuroinflammation is eliminating ultra
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processed foods.
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Things like refined sugars, industrial seed oils, packaged foods.
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These are the three biggest dietary drivers of systemic inflammation and so if you're still
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eating these regularly, no supplement is going to outdo that or overcome that.
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So you need to move toward a whole food anti inflammatory foundation.
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Things like fatty fish, colorful vegetables, leafy greens, olive oil, berries, nuts and
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seeds, quality proteins, a Mediterranean protocol or Mediterranean style diet.
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These patterns are well supported for reducing neuroinflammation and often what we utilize in
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our practice.
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For some patients, eliminating specific triggers, things like gluten, dairy, corn.
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This makes a significant difference, particularly if there's underlying gut
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permeability.
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We often use what we call a thirty day elimination protocol to identify these
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individual triggers.
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And also, the power of polyphenols comes into play.
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So, these are compounds that are found in deeply colored plants like blueberries,
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turmeric, green tea has a lot of them.
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Even, you're gonna like this one, coffee has low levels of polyphenols.
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These modulate microglial activation and actually reduce central inflammatory signaling.
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Now, the second pillar, this is a non negotiable for the brain, sleep.
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Your brain has a waste clearance system called the glymphatic system.
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It runs almost exclusively during deep, slow wave sleep.
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This is when your brain flushes out inflammatory debris, misfolded proteins,
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metabolic waste.
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If you're not getting seven to nine hours of quality sleep, your glymphatic system is
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impaired and then inflammation accumulates.
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So you need to prioritize sleep like it's medicine because it really is.
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A consistent sleep and wake time, a dark cool bedroom, no screens for at least sixty minutes
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before bed.
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Address sleep apnea if it's present.
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If you're snoring, this is something to look into.
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This is often a major and often missed driver of neuroinflammation.
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For patients who struggle with sleep and particularly sleep quality, you can use
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something like magnesium glycinate before bed.
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This is gonna help with cortisol patterns and gut health, all of which disrupt sleep
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architecture.
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Now, the third one, okay?
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Third pillar here, very important, stress and nervous system regulation.
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Chronic psychological stress drives neuroinflammation through multiple pathways.
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It elevates cortisol which compromises the blood brain barrier.
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It activates the HPA axis which keeps the immune system in a pro inflammatory state.
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And it suppresses the parasympathetic nervous system keeping your body locked in sympathetic
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overdrive.
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This is not just stress.
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The physiological consequences of chronic stress on brain tissue are real and very
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measurable.
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Tools that have strong evidence for down regulating the nervous system, here we go,
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breath work, Specifically extended exhale breathing.
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So four count in, six to eight counts out.
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This stimulates the vagus nerve and shifts you into that parasympathetic mode within minutes.
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Daily meditation, even just ten minutes has measurable effects on inflammatory cytokine
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levels.
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Cold exposure.
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Everybody knows the craze of cold plunging.
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So things like forest bathing, we call time in nature.
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All of these activate anti inflammatory pathways within the body and brain.
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For many patients, nervous system regulation is the missing piece.
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You can eat perfectly, you can take all the right supplements, you can exercise, but if
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your nervous system is chronically dysregulated, you will not heal.
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That's a massive piece of how we operate at Ascend Functional Health and one of the things
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that gets overlooked often in conventional medicine.
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Now, pillar number four, targeted supplementation.
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So let me walk through a few supplements with the strongest evidence specifically for
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neuroinflammation in this case.
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And just a quick disclaimer before this.
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None of this is me telling you to take these.
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None of this is me giving you dosages.
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You make sure based on your blood work that you know what's right for you.
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That's just the way to approach things like this.
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Now, let's get into it.
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Omega three fatty acids, specifically EPA and DHA are anti inflammatory at the neurological
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level.
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They modulate that microglial activation.
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They reduce cytokine production and support the structural integrity of neurons.
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So I recommend high quality third party tested fish oil with at least two grams combined EPA
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and DHA.
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Curcumin, this is a fantastic one, particularly when paired with omega threes.
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This is the active compound found in turmeric.
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It's one of the most studied natural inhibitors of NF kappa beta, which is a master switch for
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inflammatory gene expression in the brain.
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Now the catch, standard curcumin has poor bioavailability, it's hard for your body to
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absorb.
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So you want to look for phospholipid bound formulations often combined with black pepper
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extract.
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This makes a significant difference in efficacy The products that we use at Ascend always have
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these high levels of effectiveness.
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The next one, N Acetyl Cysteine.
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This is a precursor to glutathione which is your brain's most potent endogenous
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antioxidant.
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Oxidative stress and neuroinflammation go hand in hand.
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The NAC directly supports the brain's capacity to buffer inflammatory damage.
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Other supplements worth discussing: lion's mane mushroom, particularly for the neuro
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regenerative piece is fantastic.
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Resveratrol is another very powerful and potent antioxidant and magnesium, particularly
00:21:18
magnesium threonate which crosses the blood brain barrier very effectively.
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Now supplementation is not the only fix, should always be individualized.
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What works powerfully for one person may not for another, might even be counterproductive.
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And this is based on specific biochemistry and your drivers of inflammation.
00:21:41
The fifth pillar, exercise.
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This is probably the most underutilized anti inflammatory tool.
00:21:47
Exercise is a genuine pharmacological intervention for neuroinflammation.
00:21:52
It's gonna increase BDNF, which is brain derived neurotropic factor.
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This is what promotes neuronal health and actually heals the brain and nervous system.
00:22:02
It reduces that microglial over activation and it improves glymphatic flow.
00:22:07
It's gonna regulate cortisol, enhance your mitochondrial function in the neurons.
00:22:12
But here's where I need to insert a critical caveat.
00:22:16
Okay?
00:22:16
For patients with significant neuro inflammation, particularly those with maybe
00:22:21
mold, chronic infections or a post viral illness.
00:22:25
High intensity exercise can actually temporarily worsen your symptoms by spiking
00:22:29
inflammation further.
00:22:31
Exercise is somewhat of a stress on the body.
00:22:35
So you want to start with low intensity, consistent movement, things like walking
00:22:39
outside, swimming, maybe gentle cycling or yoga, build your tolerance.
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The goal is to get the anti inflammatory benefits of movement without triggering a
00:22:50
flare.
00:22:51
So fifteen to thirty minutes of moderate intensity exercise most days is a meaningful
00:22:55
target for patients in that position.
00:22:58
And then the pillar number six, and this is often something we support patients with, is
00:23:03
detox and drainage.
00:23:05
And so if toxins are driving neuroinflammation and in a significant percentage of patients
00:23:10
they are, reducing that toxic burden isn't an option, it's the foundation and it's often the
00:23:16
starting point.
00:23:17
Because supporting your body's drainage pathways like the liver, your lymphatic system,
00:23:22
your kidneys and your colon, these need to be moving effectively before you begin any deeper
00:23:27
type of protocol.
00:23:29
Or you could risk redistributing or pushing toxins back into circulation rather than
00:23:34
clearing them.
00:23:36
And so for liver support, like ongoing, not like strategically, but just daily, cruciferous
00:23:43
vegetables, getting adequate protein, and then targeted support with things like NAC we talked
00:23:49
about and milk thistle which is an herb.
00:23:52
These help for supporting the liver's functions in phase one and phase two detox.
00:23:58
And if you want more detox focused content, go back a few weeks to an episode that we did
00:24:04
about detox where I broke all of this down.
00:24:07
For lymphatic flow, movement, dry brushing, hydration, sauna therapy, traditional or
00:24:14
infrared, very strong evidence supporting the use of sauna for toxin elimination,
00:24:21
particularly for fat soluble compounds like mycotoxins and molds and heavy metals.
00:24:27
Start low and slow, fifteen to twenty minutes and increase maybe two to three times per week.
00:24:33
The next thing is like binder therapy.
00:24:35
Now, when it comes to binders, always do this under the supervision of a professional because
00:24:40
using things like activated charcoal, modified citrus pectin or even prescription binders like
00:24:45
cholestyramine in severe cases, this can help prevent that reabsorption of toxins as they're
00:24:52
mobilized.
00:24:53
However, if wrong can increase toxic load.
00:25:00
Identifying and removing the source of exposure is always step one.
00:25:04
Treating mold toxicity while still living in a moldy building is kind of like bailing out of a
00:25:09
sinking boat without patching the hole.
00:25:11
Right?
00:25:11
You have to always find out and remove number one.
00:25:15
So, let's summarize, let's bring all of this together.
00:25:19
Thank you for sticking with me through this.
00:25:20
I hope that a lot of this was very valuable and can be applied today.
00:25:26
Neuro inflammation is real, it's measurable, it's treatable, which is great.
00:25:31
But it sits at the root of a lot of chronic conditions that we see.
00:25:35
It's driven by upstream factors like gut dysfunction, toxins, infections, chronic
00:25:39
stress, poor sleep, but it responds to upstream interventions.
00:25:44
And so the six pillars we covered today, anti inflammatory nutrition, optimized sleep,
00:25:50
nervous system regulation, targeted supplementation, strategic exercise, and
00:25:56
drainage and detox support.
00:25:58
It's not a random list of things to try.
00:26:01
Each one of these addresses a specific mechanism in the neuroinflammatory cascade.
00:26:06
And so if you took nothing else from today, I want you to take this.
00:26:10
Your brain has a remarkable capacity to heal when you give it the right environment.
00:26:15
Neuroplasticity is real.
00:26:17
Microglial resolution is real.
00:26:20
Your biology is working, it's on your side.
00:26:23
And so the goal with us at Ascend Functional Health is never to manage your symptoms
00:26:27
indefinitely.
00:26:28
The goal is to find the root cause, remove it, and rebuild so you can feel like yourself
00:26:33
again.
00:26:35
If you're a current patient with us and this episode resonated with you, mention it to us at
00:26:40
your next appointment.
00:26:41
We can chat more about this.
00:26:43
If you're not a patient and this hit home for you or maybe someone you know, please reach out
00:26:48
to us.
00:26:49
You can go to ascendfunctionalhealth.com.
00:26:52
We can always discuss lab testing.
00:26:54
Listeners of the podcast are always going to get discounts on all kinds of lab tests and
00:26:59
supplementation.
00:27:00
You also get a special gift when you, when you reach out to us.
00:27:04
If this was beneficial or helpful, please share it.
00:27:07
That helps us.
00:27:08
We don't we don't turn a profit from this.
00:27:10
This is free, just valuable information.
00:27:13
If it's helpful, we just ask that you share it with someone who might need to hear it.
00:27:17
That's how we grow.
00:27:18
That's how we help more people become conscious of these kind of things and create a healthier
00:27:23
community all around.
00:27:24
So I thank you so much for joining me today.
00:27:27
I'm Doctor.
00:27:28
Lesse, and I look forward to seeing you on the next episode.
00:27:35
Thank you for tuning in to Health Decoded, where we break down the truth about all things
00:27:40
health and empower you to take charge of your well-being.
00:27:44
If you found value in today's episode, please subscribe, leave a review, and share it with
00:27:49
someone who needs to hear this.
00:27:51
For more resources and personalized support, visit us at alessifunctionalhealth.com and sign
00:27:57
up for our newsletter.
00:27:58
To hear your questions answered live on the show, send them to askalessifxhealth dot com.
00:28:04
That's ask@alessifxhealth.com.
00:28:10
Until next time, stay curious, stay empowered, and remember, your health is in your hands.